Bad/Considerable Metabolizers, CYP2D6 The development from the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Close to seven% from the populace has lowered exercise from the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These persons are “weak metabolizers” of debrisoquine, dextromethorphan and tricy
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